Hi,
Remeditiation is only supported for some Configuration items: "You can remediate noncompliant settings for WMI, the registry, scripts, and all settings for the mobile devices that are enrolled by Configuration Manager." So for a folder you would have to make a Collection of "non-compliant" computers and deploy a script to that Collection that deletes the folder.
I am not much femiliar with Complaint & Remidiation Process.
But if its your requiremnt You can create a deployement type with detection method and uninstall if application present in machine .
if multiple application need to uninstall use some script to call uninstalltion process for application
thanks