In addition to Sathish & Jim below are some steps:
A very common Exchange 2010 NDR, the cause is a permissions problem. For some reason the sender is not allowed to email this account.
Perhaps an anonymous user is trying to send mail to a distribution list.
Alternatively, a user may have a manually created email address that does not match a System Policy.
Check SMTP Virtual Server Access Tab. Try checking this box: Allow computers which successfully authenticate to relay.
Check the outgoing SMTP logs.
Check: Mailbox <Mailboxname> Properties Mail Flow Settings Message delivery restrictions.
Try disabling Windows-Integrated-Security. Instead allow only standard authorization on the SMTP receiver on the Exchange 2010 server.
----------------------------------------------------------------------
Remember to mark as helpful if you find my contribution useful or as an answer if it does answer your question.That will encourage me - and others - to take time out to help you Check out my latest blog posts @ Techrid.com