I am not an exchange expert at all, our users cannot connect using mobile devices after upgrading to exchange 2010. I read to try the following (below) and it works, but I can do this for 1500 users. I'm sure there's got to be a way to set this in mass. Any help is appreciated on how to accomplish this task. I did try applying this to an OU, but it doesn't seem to take affect. Do I need to restart the DCs maybe? Thanks

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To work around this issue, assign the Exchange Servers group the right to change permissions against msExchActiveSyncDevices objects. To do this, follow these steps:

1. Start Active Directory Users and Computers.
2. Click View, and then click to enable Advanced Features.
3. Right-click the object where you want to change the Exchange Server permissions, and then click Properties.
   
   Note You can change permissions against a user, an organizational unit, or a domain.
4. On the Security tab, click Advanced.
5. Click Add, type Exchange Servers, and then click OK.
6. In the Apply to box, click Descendant msExchActiveSyncDevices objects.
7. Under Permissions, click to enable Modify Permissions.
8. Click OK three times.

Upgrading from which version of Exchange to Exchange 2010?

Are you able the logon to Outlook Web Access?

To make sure if your Exchange is configured for OWA and Mobile DEvice Connectivity use this url

www.TestExchangeConnectivity.com