Hi Greg,
This is normal behavior, because the address that you replied to was just a name, the on-premises Active Directory Domain Services (AD DS) can't locate the user in order to route the mail correctly.
When you fill with full email address, your organization can route to the correct address through resolving the domain name.
Here are some similar thread for your reference:
https://support.microsoft.com/kb/2685437/en-us
Best regards,