Hi,

I'm Facing issue in Excel after installation of O365 Pro Plus.

Excel File not opening on Double Click. It is working if open 

File -> Open -> .xlxs

what may be the issue. I tried repair also not working.

Hi Hari Prasad.D,

Could you tell me if this issue only appeared in Excel?

First I suggest you if it works fine for other Office programs (e.g. WORD, PPT)

Then you need to check if it only appeared in .xlsx file. Try to create a .xls and .xlsm samples, and check if they work fine.

Based on your issue, I provide several methods to help you.

Method 1:

Try to Re-register Excel, open RUN dialog box and type excel /unregserver, click OK. Then reopen RUN dialog box and type excel /regserver, click OK.

Now please check if you can double click Excel file and open it.

Method 2:

If it only appeared in Excel:

Please open a blank Excel file and go to File > Options > Advanced > General Section > Tick the option "Ignore other application that use Dynamic Data Exchange"

Method 3:

Try to restore Office file associations, please refer to this article:

http://blog.jasonsamuels.net/post/44806860956/fixing-an-excel-file-type-association-after

Please Note: Since the web site is not hosted by Microsoft, the link may change without notice. Microsoft does not guarantee the accuracy of this information.

Please try these methods and check if they work for you. I'm glad to help and follow up your reply.

Hope it's helpful.

Regards,

Emi Zhang
TechNet Community Su