It was my understanding that Exchange 2007 SP3 was now supported on Windows 2008 R2 x64 but I have a fresh installation of both and when trying to run the Exchange Management Shell I get the following error. "Internal Windows PowerShell error. COM initialization failed while reading Windows PowerShell console file with error 80010106." The shortcut path is: C:\Windows\System32\WindowsPowerShell\v1.0\powershell.exe -PSConsoleFile "C:\Program Files\Microsoft\Exchange Server\bin\exshell.psc1" -noexit -command ". 'C:\Program Files\Microsoft\Exchange Server\bin\Exchange.ps1'" Right-click, Run As Administrator on the shortcut makes no difference. If I browse to and launch "C:\Program Files\Microsoft\Exchange Server\Bin\exshell.psc1" directly I get exactly the same error message. If I launch Powershell manually and then run.. Add-PSSnapin Microsoft.Exchange.Management.PowerShell.admin Add-PSSnapin Microsoft.Exchange.Management.PowerShell.Support I can run Exchange Powershell cmdlets without any problems?! Any ideas what could be causing this? I've compared exshell.psc1 with the same file on a (working) Server 2003 x64 box and the files are identical. No error messages of any kind in the Event Logs - I'm a bit stumped! Any advice would be really appreciated, I've been tearing my hair out for the last few hours on this. Someone had a similar problem with the Exchange Management Shell on Windows 7 64bit at http://www.experts-exchange.com/Software/Server_Software/Email_Servers/Exchange/Q_25481660.html but there's no real fix listed.

Well it looks like this is more Powershell related than Exchange 2007. If I open Powershell and "export-console .\test.psc1" and then try and open that console file, I get exactly the same error message.. so something is screwy with Powershell.. I'll post there instead.. no idea what can be done to fix it tho considering Powershell is 'bundled' with 2008 R2.

Just in case anyone else ever has this problem.. I found the cause. http://social.technet.microsoft.com/Forums/en/winserverpowershell/thread/ecf0a798-46d5-4925-8174-4f47dd5d332e If you change the 'Number of recent items to display in jump lists' to 0 under the Start Menu Properties / Customize it will cause Windows Powershell to fail to open with the COM initialization error message whenever you're opening a 'Console File' / .psc1 file. A ridiculous issue but I can reproduce the problem by changing it to 10 and then back to 0.. works / fails every time.

Can you try uninstalling and reinstalling it?

Can you try uninstalling and reinstalling it?