Hi Michael,
Exchange 2013 servers fully support IPv6 networks. Therefore, even if you aren't using IPv6, you don't need to disable IPv6 on your Exchange servers.
Microsoft recommendation is to leave there even if you are not using IPv6.
Disabling it should not break anything as such, keeping it on doesn't hurt as well (similar to keep the UM service running on CAS, MBX)
"Because Windows was designed specifically with IPv6 present, Microsoft does not perform any testing to determine the effects of disabling IPv6. If IPv6 is disabled on Windows 7, Windows Vista, Windows Server 2008 R2, or Windows Server 2008, or later
versions, some components will not function. Moreover, applications that you might not think are using IPv6such as Remote Assistance, HomeGroup, DirectAccess, and Windows Mailcould be."
Some useful information:
Disabling IPv6 And Exchange Going All The Way
http://blogs.technet.com/b/rmilne/archive/2014/10/29/disabling-ipv6-and-exchange-_1320_-going-all-the-way.aspx
IPv6 support in Exchange 2013
https://technet.microsoft.com/en-us/library/gg144561(v=exchg.150).aspx
Q. What are Microsoft's recommendations about disabling IPv6?
https://technet.microsoft.com/en-us/network/cc987595.aspx