Hi,
First of all, we need to know more about 6to4 adapter.
6to4 is an address assignment and router-to-router, host-to-router, and router-to-host automatic tunneling technology that is used to provide unicast IPv6 connectivity between IPv6 sites and hosts across the IPv4 Internet. 6to4 treats the entire IPv4 Internet
as a single link.
For example, your CAS server is configured from a public range IPv4 address 20.1.1.11 as shown in the IPCONFIG output. Assume IPv6 is also enabled and there is no global IPv6 address explicitly configured in your server. The
default behavior in Windows is to generate 6to4 tunnel address and in this case is configured in the 6to4 Adapter section of IPCONFIG output.
The 6to4 tunnel address always starts with a 2002. The remaining digits 1401:10C are generated based out of the IPv4 address that is configured on your server and it gets repeated in the interface ID portion also. It is basically hex representation of IPv4
address values. If you convert the decimal digit 20 to a hex value, it is 14, 1 becomes 01 in hex and so on.
If you want to know more about how the tunneling technologies work, review the white paper in this TechNet link
https://technet.microsoft.com/en-us/library/bb726951.aspx
So enabling or disabling the 6to4 adapter is depending on your preferences.
More information about 6to4 adapter, you can refer to this blog.
http://blogs.technet.com/b/askpfeplat/archive/2013/11/18/ipv6-for-the-windows-administrator-the-2002-6to4-tunnel-address-and-its-impact.aspx
Best Regards.