Hello Manu,
Thank you so much for the reply.
Here is the log file
#Software: Microsoft Exchange Server
#Version: 8.0.0.0
#Log-type: SMTP Send Protocol Log
#Date: 2015-07-09T07:01:22.357Z
#Fields: date-time,connector-id,session-id,sequence-number,local-endpoint,remote-endpoint,event,data,context
2015-07-09T07:01:22.357Z,Smtp Send Connector,08D288139CE8E5B2,0,,2404:6800:4003:c00::1b:25,*,,attempting to connect
2015-07-09T07:01:22.357Z,Smtp Send Connector,08D288139CE8E5B2,1,,2404:6800:4003:c00::1b:25,*,,"Failed to connect. Error Code: 10051, Error Message: A socket operation was attempted to an unreachable network 2404:6800:4003:c00::1b:25"
2015-07-09T07:01:22.357Z,Smtp Send Connector,08D288139CE8E5B2,0,,74.125.200.27:25,*,,attempting to connect
2015-07-09T07:01:22.357Z,Smtp Send Connector,08D288139CE8E5B2,1,192.168.2.12:24478,74.125.200.27:25,+,,
2015-07-09T07:01:22.528Z,Smtp Send Connector,08D288139CE8E5AD,0,,2404:6800:4003:c00::1b:25,*,,attempting to connect
2015-07-09T07:01:22.528Z,Smtp Send Connector,08D288139CE8E5AD,1,,2404:6800:4003:c00::1b:25,*,,"Failed to connect. Error Code: 10051, Error Message: A socket operation was attempted to an unreachable network 2404:6800:4003:c00::1b:25"
2015-07-09T07:01:22.528Z,Smtp Send Connector,08D288139CE8E5AD,0,,74.125.200.27:25,*,,attempting to connect
2015-07-09T07:01:22.528Z,Smtp Send Connector,08D288139CE8E5AD,1,192.168.2.12:24480,74.125.200.27:25,+,,
2015-07-09T07:01:26.091Z,Smtp Send Connector,08D288139CE8E5F2,0,,195.74.38.202:25,*,,attempting to connect