I'm currently running an exchange 2003 sp2 on a Windows 2003 SP1 Domain Controller with Mcafee virus scan 8.00 Its been running fine for about a year. Recently the information store terminates intermittently with the following error. I can restart the Microsoft Exchange Information Store service Event Type: Error Event Source: Service Control Manager Event Category: None Event ID: 7024 Date: 19/09/2006 Time: 21:54:43 User: N/A Computer: ICCUK-MAIL2 Description: The Microsoft Exchange Information Store service terminated with service-specific error 0 (0x0). I've installed Exchange Best Practice analyzer and Exchange Troubleshooting Assistant v1.0 and there are no critical errors. I've also followed this KB's http://support.microsoft.com/?kbid=285116 I also get the following errors in the application log Event Type: Error Event Source: MSExchangeFBPublish Event Category: General Event ID: 8197 Date: 20/09/2006 Time: 06:08:28 User: N/A Computer: ICCUK-MAIL2 Description: Error initializing session for virtual machine ICCUK-MAIL2. The error number is 0x8004011d. Make sure Microsoft Exchange Store is running. Event Type: Error Event Source: MSExchangeSA Event Category: MAPI Session Event ID: 9175 Date: 20/09/2006 Time: 05:00:27 User: N/A Computer: ICCUK-MAIL2 Description: The MAPI call 'OpenMsgStore' failed with the following error: Your profile is not configured. An unexpected, unknown error has occurred. Microsoft Exchange Server Information Store ID no: 8004011c-0521-00000000 Event Type: Error Event Source: MSExchangeTransport Event Category: NDR Event ID: 3005 Date: 20/09/2006 Time: 14:32:30 User: N/A Computer: ICCUK-MAIL2 Description: A non-delivery report with a status code of 4.4.6 was generated for recipient rfc822;l.c...@lowefusion.co.uk (Message-ID <Kilauea168229-73086-129287585-3-1...@flonetwork.com>). Cause: The maximum hop count was exceeded for this message. This non-delivery report can also be caused if a looping condition exists between sending and receiving servers that are not in the same Exchange organization. In this situation, the message bounces back and forth until the hop count is exceeded. A configuration error in the e-mail system can also cause the message to bounce between two servers or to be forwarded between two recipients. Solution: The maximum hop count is a property set on each virtual server and you can manually override it. The default maximum hop count is 15. Also, check for any situations that might cause loops between servers.