Dear All . 

we have exchange server 2013 RTM currently single server and when trying to access out from out side we are getting ERR_CONNECTION_CLOSED and sometimes it is working and sometimes it is not .

also sometimes from IE Browser it is working and from Google Chrome it is not !!

is this something related to the Certificate ? 

where to start troubleshoot !!

update exchange to CU7 will solve the issue !

owa working internally and no problem 

also recently we have renews the SAN Certificate .

• Edited by JavaHeart Tuesday, June 16, 2015 10:29 AM

Mcafee has an SSL content inspection option. Can you disable this temporarily and see if that improves the connection ? 

"If your particular SSL application doesn't work when SSL content inspection is configured, it may be incompatible. Use passthrough instead for the SSL application. To use passthrough, configure a new SSL policy rule for the endpoints in the audit message with an action of No Decryption, and then place that rule above your Re-encrypt rule."

• Edited by Knob Country Tuesday, June 16, 2015 2:24 PM

Can you post a screen shot of what you see when it's not working?  Was it working and stopped?  Is there a new cert in use?  If so, can you temporarily revert to the old cert and see if access works again?  Is the issue affecting one user or all users?  Please provide as much information a