I have always used Outlook app in 365 until I wanted to use Skype for Business. So I set up outlook 2010 on my desktop and I get this message. "Msft exchange is unavailable. Outlook must be online or connected to complete this action" What does this mean???

Hi,

Which outlook account are you used, Exchange account or Office 365 account?
How about repair Outlook profile or recreate Outlook profile? For your reference:
https://support.office.com/en-za/article/Repair-Outlook-Data-Files-pst-and-ost-25663bc3-11ec-4412-86c4-60458afc5253

Thanks

You are getting that error because your profile has got corrupt and in order to get rid of the same, you need to delete the existing profile and recreate your Outlook profile. For more info, visit https://www.interworks.com/blogs/esprague/2013/07/15/microsoft-outlook-exchange-unavailable-outlook-must-be-online-or-connected

• Edited by Blake Jason 22 hours 35 minutes ago