many things to consider and ask yourself
it is only happening to Outlook clients , if so then do they have all similar outlook clients? are they wired or on wi-fi connection?
does it also happen to their email on mobile device or just outlook?
it could be a network issue, make sure packets are not dropping and you need to ask your network guy to run some test.
Hi,
In addition to the above suggestions, I recommend you recycle the following Application Pools and check the result.
Exchange 2013 CAS Server: MSExchangeAutodiscoverAppPool, MSExchangeRpcProxyFrontEndAppPool
Exchange 2013 Mailbox Server: MSExchangeAutodiscoverAppPool, MSExchangeRpcProxyAppPool
Hope this can be helpful to you.
Best regards,
If you have feedback for TechNet Subscriber Support, contact tnmff@microsoft.c