I have a Windows 2008 AD domain with windows 2003 sp2 Windows Servers running Exchange 2007 Sp1 Rp2. We have an internal domain that is different to our external domain. On one of the CAS server there are two nic and two IIS instances with different certs providing access to the internal services for the clients and the other providing OWA and Activesync services through ISA2006 in the DMZ Externally. This is functioning as intended. I have installed the RPC service on the Windows 2003 box, setup Outlookanywhere through the EMC. THe intial install was on the first nic which was the internal network domain name. I got OA successfully connecting to the internal domain (nic 1) on the server. Since then I have made a copy of the Virtual directories in the second instance of IIS and then tried to test this instance internally the OA serivce won't connect. I am not seeing any errors. Is there something I have to do to get the RPC service to work on the second Nic? I am trying to test this internally (Host file entry for external domain) before publishing it through ISA.Thanks for your help in advance.Matt

Try something really basic to see if the RPC service is responding on the second NIC. let's say that 10.1.1.1 is the IP address of the second NIC.... try to connect to http://10.1.1.1/rpc and see if you are challeged for credentials or not.

also testthe /autodiscover directory in IIS with https://internalservernameFQDN/autodiscover/autodiscovery.xml you chould get prompted for credentials and after entering them you should get XML string back.