My wife after down loading pictures used the "Safely remove hardware" on all my drives. Now none of my USB ports work. I've uninstalled them and restarted the computer, I've turn on or enabled everything to do with plug and play devices. Under device manager all the USB ports are there and they are all working properly however nothing that I plug into them will work.2 people need an answerI do too

Before you try anything else shut the computer down and disconnect the power cord, then, obviously, reconnect it and restart the computer. For whatever reason, this will sometimes "reset" the motherboard's electrics and restart the power to the USB ports.