Hi,
Did you enable Kerberos authentication for Lync Mac?
When connected to the internal corporate network (LAN), make sure enable Kerberos authentication for Lync for Mac, verify that the Kerberos plug-in has been enabled in Mac OS X and is working correctly.
More details:
Best Regards,
Eason Huang
The Lync client typically uses TCP port 5061 for network communications in an on-premises environment.
Also check below link
http://jackstromberg.com/2012/10/lync-2010-server-lync-2011-for-mac-clients-failing-to-connect/
http://technet.microsoft.com/en-us/library/jj945442%28v=office.14%29.aspx