Hi,
I have capture a trace when changing the pointer speed settings, and noticed that following things can be related:
3:02:56.9312712 PM rundll32.exe 2524 RegOpenKey HKCU\Control Panel\Mouse SUCCESS Desired Access: Write
3:02:56.9312959 PM rundll32.exe 2524 RegQueryKeySecurity HKCU\Control Panel\Mouse SUCCESS
3:02:56.9313069 PM rundll32.exe 2524 RegSetValue HKCU\Control Panel\Mouse\MouseTrails SUCCESS Type: REG_SZ, Length: 4, Data: 0
3:02:56.9313281 PM rundll32.exe 2524 RegCloseKey HKCU\Control Panel\Mouse SUCCESS
3:02:56.9482047 PM rundll32.exe 2524 RegOpenKey HKCU\Control Panel\Mouse SUCCESS Desired Access: Write
3:02:56.9482203 PM rundll32.exe 2524 RegQueryKeySecurity HKCU\Control Panel\Mouse SUCCESS
3:02:56.9482288 PM rundll32.exe 2524 RegSetValue HKCU\Control Panel\Mouse\MouseThreshold1 SUCCESS Type: REG_SZ, Length: 4, Data: 6
3:02:56.9482424 PM rundll32.exe 2524 RegCloseKey HKCU\Control Panel\Mouse SUCCESS
3:02:56.9482535 PM rundll32.exe 2524 RegOpenKey HKCU\Control Panel\Mouse SUCCESS Desired Access: Write
3:02:56.9482613 PM rundll32.exe 2524 RegQueryKeySecurity HKCU\Control Panel\Mouse SUCCESS
3:02:56.9482665 PM rundll32.exe 2524 RegSetValue HKCU\Control Panel\Mouse\MouseThreshold2 SUCCESS Type: REG_SZ, Length: 6, Data: 10
3:02:56.9482740 PM rundll32.exe 2524 RegCloseKey HKCU\Control Panel\Mouse SUCCESS
3:02:56.9482832 PM rundll32.exe 2524 RegOpenKey HKCU\Control Panel\Mouse SUCCESS Desired Access: Write
3:02:56.9482899 PM rundll32.exe 2524 RegQueryKeySecurity HKCU\Control Panel\Mouse SUCCESS
3:02:56.9482947 PM rundll32.exe 2524 RegSetValue HKCU\Control Panel\Mouse\MouseSpeed SUCCESS Type: REG_SZ, Length: 4, Data: 1
3:02:56.9483013 PM rundll32.exe 2524 RegCloseKey HKCU\Control Panel\Mouse SUCCESS
3:02:56.9631606 PM rundll32.exe 2524 RegOpenKey HKCU\Control Panel\Mouse SUCCESS Desired Access: Write
3:02:56.9631754 PM rundll32.exe 2524 RegQueryKeySecurity HKCU\Control Panel\Mouse SUCCESS
3:02:56.9631837 PM rundll32.exe 2524 RegSetValue HKCU\Control Panel\Mouse\MouseSensitivity SUCCESS Type: REG_SZ, Length: 6, Data: 20
3:02:56.9631956 PM rundll32.exe 2524 RegCloseKey HKCU\Control Panel\Mouse SUCCESS
3:02:59.6267607 PM rundll32.exe 2524 RegOpenKey HKCU\Control Panel\Mouse SUCCESS Desired Access: Write
3:02:59.6267860 PM rundll32.exe 2524 RegQueryKeySecurity HKCU\Control Panel\Mouse SUCCESS
3:02:59.6267966 PM rundll32.exe 2524 RegSetValue HKCU\Control Panel\Mouse\MouseTrails SUCCESS Type: REG_SZ, Length: 4, Data: 0
3:02:59.6268188 PM rundll32.exe 2524 RegCloseKey HKCU\Control Panel\Mouse SUCCESS
3:02:59.6542026 PM rundll32.exe 2524 RegOpenKey HKCU\Control Panel\Mouse SUCCESS Desired Access: Write
3:02:59.6542174 PM rundll32.exe 2524 RegQueryKeySecurity HKCU\Control Panel\Mouse SUCCESS
3:02:59.6542264 PM rundll32.exe 2524 RegSetValue HKCU\Control Panel\Mouse\MouseThreshold1 SUCCESS Type: REG_SZ, Length: 4, Data: 6
3:02:59.6542425 PM rundll32.exe 2524 RegCloseKey HKCU\Control Panel\Mouse SUCCESS
3:02:59.6542537 PM rundll32.exe 2524 RegOpenKey HKCU\Control Panel\Mouse SUCCESS Desired Access: Write
3:02:59.6542619 PM rundll32.exe 2524 RegQueryKeySecurity HKCU\Control Panel\Mouse SUCCESS
3:02:59.6542673 PM rundll32.exe 2524 RegSetValue HKCU\Control Panel\Mouse\MouseThreshold2 SUCCESS Type: REG_SZ, Length: 6, Data: 10
3:02:59.6542754 PM rundll32.exe 2524 RegCloseKey HKCU\Control Panel\Mouse SUCCESS
3:02:59.6542848 PM rundll32.exe 2524 RegOpenKey HKCU\Control Panel\Mouse SUCCESS Desired Access: Write
3:02:59.6542922 PM rundll32.exe 2524 RegQueryKeySecurity HKCU\Control Panel\Mouse SUCCESS
3:02:59.6542972 PM rundll32.exe 2524 RegSetValue HKCU\Control Panel\Mouse\MouseSpeed SUCCESS Type: REG_SZ, Length: 4, Data: 1
3:02:59.6543039 PM rundll32.exe 2524 RegCloseKey HKCU\Control Panel\Mouse SUCCESS
3:02:59.6805470 PM rundll32.exe 2524 RegOpenKey HKCU\Control Panel\Mouse SUCCESS Desired Access: Write
3:02:59.6805642 PM rundll32.exe 2524 RegQueryKeySecurity HKCU\Control Panel\Mouse SUCCESS
3:02:59.6805739 PM rundll32.exe 2524 RegSetValue HKCU\Control Panel\Mouse\MouseSensitivity SUCCESS Type: REG_SZ, Length: 6, Data: 20
3:02:59.6805901 PM rundll32.exe 2524 RegCloseKey HKCU\Control Panel\Mouse SUCCESS
3:02:59.7071591 PM rundll32.exe 2524 RegOpenKey HKLM\SOFTWARE\Microsoft\CTF\KnownClasses NAME NOT FOUND Desired Access: Read
3:02:59.7107278 PM rundll32.exe 2524 RegOpenKey HKLM\Software\Microsoft\Windows\CurrentVersion\Control Panel\DoNotUnload SUCCESS Desired Access: Query Value
3:02:59.7107462 PM rundll32.exe 2524 RegQueryValue HKLM\SOFTWARE\Microsoft\Windows\CurrentVersion\Control Panel\DoNotUnload\main.cpl NAME NOT FOUND Length: 144
3:02:59.7107529 PM rundll32.exe 2524 RegCloseKey HKLM\SOFTWARE\Microsoft\Windows\CurrentVersion\Control Panel\DoNotUnload SUCCESS
3:02:59.7109743 PM rundll32.exe 2524 CloseFile C:\Windows\System32\en-US\main.cpl.mui SUCCESS
3:02:59.7129870 PM rundll32.exe 2524 CloseFile C:\Windows\winsxs\x86_microsoft.windows.common-controls_6595b64144ccf1df_6.0.7601.18807_none_41e554362bd82458 SUCCESS
3:02:59.7131942 PM rundll32.exe 2524 CloseFile C:\Windows\winsxs\x86_microsoft.windows.common-controls_6595b64144ccf1df_6.0.7601.18807_none_41e554362bd82458 SUCCESS
3:02:59.7132774 PM rundll32.exe 2524 RegOpenKey HKLM\Software\Microsoft\Windows NT\CurrentVersion\GRE_Initialize SUCCESS Desired Access: Read
3:02:59.7132981 PM rundll32.exe 2524 RegQueryValue HKLM\SOFTWARE\Microsoft\Windows NT\CurrentVersion\GRE_Initialize\DisableMetaFiles NAME NOT FOUND Length: 20
3:02:59.7133040 PM rundll32.exe 2524 RegCloseKey HKLM\SOFTWARE\Microsoft\Windows NT\CurrentVersion\GRE_Initialize SUCCESS
3:02:59.7133313 PM rundll32.exe 2524 Thread Exit SUCCESS Thread ID: 2728, User Time: 0.0312500, Kernel Time: 0.0468750
3:02:59.7150524 PM rundll32.exe 2524 QueryNameInformationFile C:\Windows\System32\rundll32.exe SUCCESS Name: \Windows\System32\rundll32.exe
3:02:59.7150987 PM rundll32.exe 2524 QueryNameInformationFile C:\Windows\AppPatch\AcLayers.dll SUCCESS Name: \Windows\AppPatch\AcLayers.dll
3:02:59.7151297 PM rundll32.exe 2524 QueryNameInformationFile C:\Windows\System32\winspool.drv SUCCESS Name: \Windows\System32\winspool.drv
3:02:59.7154472 PM rundll32.exe 2524 QueryNameInformationFile C:\Windows\System32\mpr.dll SUCCESS Name: \Windows\System32\mpr.dll
3:02:59.7154725 PM rundll32.exe 2524 QueryNameInformationFile C:\Windows\System32\dwmapi.dll SUCCESS Name: \Windows\System32\dwmapi.dll
3:02:59.7154918 PM rundll32.exe 2524 QueryNameInformationFile C:\Windows\System32\uxtheme.dll SUCCESS Name: \Windows\System32\uxtheme.dll
3:02:59.7155103 PM rundll32.exe 2524 QueryNameInformationFile C:\Windows\winsxs\x86_microsoft.windows.common-controls_6595b64144ccf1df_6.0.7601.18807_none_41e554362bd82458\comctl32.dll SUCCESS Name: \Windows\winsxs\x86_microsoft.windows.common-controls_6595b64144ccf1df_6.0.7601.18807_none_41e554362bd82458\comctl32.dll
3:02:59.7155286 PM rundll32.exe 2524 QueryNameInformationFile C:\Windows\System32\sspicli.dll SUCCESS Name: \Windows\System32\sspicli.dll
3:02:59.7155458 PM rundll32.exe 2524 QueryNameInformationFile C:\Windows\System32\apphelp.dll SUCCESS Name: \Windows\System32\apphelp.dll
3:02:59.7155630 PM rundll32.exe 2524 QueryNameInformationFile C:\Windows\System32\cryptbase.dll SUCCESS Name: \Windows\System32\cryptbase.dll
3:02:59.7155802 PM rundll32.exe 2524 QueryNameInformationFile C:\Windows\System32\profapi.dll SUCCESS Name: \Windows\System32\profapi.dll
3:02:59.7156002 PM rundll32.exe 2524 QueryNameInformationFile C:\Windows\System32\KernelBase.dll SUCCESS Name: \Windows\System32\KernelBase.dll
3:02:59.7156175 PM rundll32.exe 2524 QueryNameInformationFile C:\Windows\System32\userenv.dll SUCCESS Name: \Windows\System32\userenv.dll
3:02:59.7156342 PM rundll32.exe 2524 QueryNameInformationFile C:\Windows\System32\usp10.dll SUCCESS Name: \Windows\System32\usp10.dll
3:02:59.7156513 PM rundll32.exe 2524 QueryNameInformationFile C:\Windows\System32\user32.dll SUCCESS Name: \Windows\System32\user32.dll
3:02:59.7156678 PM rundll32.exe 2524 QueryNameInformationFile C:\Windows\System32\gdi32.dll SUCCESS Name: \Windows\System32\gdi32.dll
3:02:59.7156841 PM rundll32.exe 2524 QueryNameInformationFile C:\Windows\System32\lpk.dll SUCCESS Name: \Windows\System32\lpk.dll
3:02:59.7157006 PM rundll32.exe 2524 QueryNameInformationFile C:\Windows\System32\imagehlp.dll SUCCESS Name: \Windows\System32\imagehlp.dll
3:02:59.7157170 PM rundll32.exe 2524 QueryNameInformationFile C:\Windows\System32\advapi32.dll SUCCESS Name: \Windows\System32\advapi32.dll
3:02:59.7157357 PM rundll32.exe 2524 QueryNameInformationFile C:\Windows\System32\msvcrt.dll SUCCESS Name: \Windows\System32\msvcrt.dll
3:02:59.7157526 PM rundll32.exe 2524 QueryNameInformationFile C:\Windows\System32\imm32.dll SUCCESS Name: \Windows\System32\imm32.dll
3:02:59.7157695 PM rundll32.exe 2524 QueryNameInformationFile C:\Windows\System32\shlwapi.dll SUCCESS Name: \Windows\System32\shlwapi.dll
3:02:59.7157857 PM rundll32.exe 2524 QueryNameInformationFile C:\Windows\System32\shell32.dll SUCCESS Name: \Windows\System32\shell32.dll
3:02:59.7158021 PM rundll32.exe 2524 QueryNameInformationFile C:\Windows\System32\sechost.dll SUCCESS Name: \Windows\System32\sechost.dll
3:02:59.7158180 PM rundll32.exe 2524 QueryNameInformationFile C:\Windows\System32\rpcrt4.dll SUCCESS Name: \Windows\System32\rpcrt4.dll
3:02:59.7158350 PM rundll32.exe 2524 QueryNameInformationFile C:\Windows\System32\oleaut32.dll SUCCESS Name: \Windows\System32\oleaut32.dll
3:02:59.7158517 PM rundll32.exe 2524 QueryNameInformationFile C:\Windows\System32\msctf.dll SUCCESS Name: \Windows\System32\msctf.dll
3:02:59.7158708 PM rundll32.exe 2524 QueryNameInformationFile C:\Windows\System32\ole32.dll SUCCESS Name: \Windows\System32\ole32.dll
3:02:59.7158879 PM rundll32.exe 2524 QueryNameInformationFile C:\Windows\System32\kernel32.dll SUCCESS Name: \Windows\System32\kernel32.dll
3:02:59.7159050 PM rundll32.exe 2524 QueryNameInformationFile C:\Windows\System32\ntdll.dll SUCCESS Name: \Windows\System32\ntdll.dll
3:02:59.7159222 PM rundll32.exe 2524 QueryNameInformationFile C:\Windows\System32\apisetschema.dll SUCCESS Name: \Windows\System32\apisetschema.dll
3:02:59.7159741 PM rundll32.exe 2524 Process Exit SUCCESS Exit Status: 0, User Time: 0.0312500 seconds, Kernel Time: 0.0468750 seconds, Private Bytes: 1,462,272, Peak Private Bytes: 1,544,192, Working Set: 5,636,096, Peak Working Set: 5,926,912
3:02:59.7159843 PM rundll32.exe 2524 CloseFile C:\Windows\System32 SUCCESS
3:02:59.7160115 PM rundll32.exe 2524 RegCloseKey HKLM\System\CurrentControlSet\Control\Session Manager SUCCESS
3:02:59.7160385 PM rundll32.exe 2524 RegCloseKey HKLM\System\CurrentControlSet\Control\Nls\Sorting\Versions SUCCESS
3:02:59.7161905 PM rundll32.exe 2524 CloseFile C:\Windows\System32\en-US\rundll32.exe.mui SUCCESS
3:02:59.7162098 PM rundll32.exe 2524 RegCloseKey HKLM SUCCESS
3:02:59.7162189 PM rundll32.exe 2524 RegCloseKey HKLM\System\CurrentControlSet\Control\NetworkProvider\HwOrder SUCCESS
3:02:59.7162343 PM rundll32.exe 2524 RegCloseKey HKCU SUCCESS
3:02:59.7162417 PM rundll32.exe 2524 RegCloseKey HKCU\Software\Microsoft\Windows NT\CurrentVersion SUCCESS
3:02:59.7162457 PM rundll32.exe 2524 RegCloseKey HKLM\SOFTWARE\Microsoft\Windows NT\CurrentVersion\AppCompatFlags SUCCESS
3:02:59.7162514 PM rundll32.exe 2524 CloseFile C:\Windows\winsxs\x86_microsoft.windows.common-controls_6595b64144ccf1df_6.0.7601.18807_none_41e554362bd82458 SUCCESS
3:02:59.7162665 PM rundll32.exe 2524 CloseFile C:\Windows\winsxs\x86_microsoft.windows.c..-controls.resources_6595b64144ccf1df_6.0.7600.16385_en-us_581cd2bf5825dde9 SUCCESS
3:02:59.7162794 PM rundll32.exe 2524 CloseFile C:\Windows\winsxs\x86_microsoft.windows.c..-controls.resources_6595b64144ccf1df_6.0.7600.16385_en-us_581cd2bf5825dde9\comctl32.dll.mui SUCCESS
3:02:59.7162930 PM rundll32.exe 2524 RegCloseKey HKLM\System\CurrentControlSet\Control\Nls\Locale SUCCESS
3:02:59.7162968 PM rundll32.exe 2524 RegCloseKey HKLM\System\CurrentControlSet\Control\Nls\Locale\Alternate Sorts SUCCESS
3:02:59.7163006 PM rundll32.exe 2524 RegCloseKey HKLM\System\CurrentControlSet\Control\Nls\Language Groups SUCCESS
3:02:59.7163051 PM rundll32.exe 2524 CloseFile C:\Windows\Fonts\StaticCache.dat SUCCESS
And rundll32.exe read and write data in above registry keys when you change the settings.
I recommend you use Process monitor to capture the system events during repro the issue and filter with Process name rundll32.exe:
Compare with my trace here and pay attention if there is any access denied error in your environment.
Process Monitor v3.05
http://technet.microsoft.com/en-us/sysinternals/bb896645.aspx
Solving Access Denied Errors Using Process Monitor
http://improve.dk/solving-access-denied-errors-using-process-monitor/