Hi Jacob,
Please have a look at the following articles.
"If you use a third-party file-level antivirus program on a server containing Forefront Protection 2010 for Exchange Server (FPE), to prevent corruption of FPE, you must ensure that the following program folders are not scanned:
-
The folder into which you installed FPE. For more information about the default installation folder, see
Default folders.
-
The folder in which you installed Microsoft Exchange Server.
The file-level antivirus scan can also cause a conflict when FPE tries to scan e-mail messages."
Reference:https://technet.microsoft.com/en-us/library/dd639351.aspx
"To ensure comprehensive protection, Microsoft Forefront Protection 2010 for Exchange Server (FPE) can be deployed on Exchange Edge Transport, Hub Transport, Mailbox server, or combined Hub/Mailbox roles."
Reference:https://technet.microsoft.com/en-us/library/protectingexchangeserverswithforefront.aspx
Best Regards,
Joyce