I've installed both Windows 8.1 and Windows 7 on a Dell Latitude E5400 and in both cases whenever any user logs in (administrator or otherwise) the Taskbar is unresponsive. Icons don't highlight on hover or start when clicked and I can't open the start menu. It seems like Explorer is partially functional, as I can open new Explorer windows via keyboard shortcut. Once they're open, however, they are completely unresponsive. I can also start applications through desktop icons, but once they're running they don't seem to recognize mouse or keyboard input. Like I said, the laptop behaves exactly the same with both OSs, which leads me to believe it's a hardware or driver issue.
What's most interesting to me is that if I enter the Windows Security Screen by pressing control+alt+delete, it is unresponsive at first (options don't highlight on hover, etc), but if I click anywhere on the screen (while I'm in the Security Screen) all problems are magically fixed. I can use the Security Screen and return to the desktop and the Taskbar works fine as well as all the applications that were frozen before.
I've looked and it seems like all drivers are installed and up to date. I can't imagine what would cause it to behave like this across multiple editions of Windows. If anyone has any ideas I'd love to hear them!